mp2rage - Create MP2RAGE image
The complex image data acquired by an inversion recovery MR scan is often
represented in the form of its modulus, as the real and imaginary images can
suffer from the effect of magnetic field inhomogeneities which generate
phase shifts between them. However, if additional information can be obtained
to correct this phase shift, then the real image can be calculated. One method
to achieve this involves acquiring complex images with two inversion times,
fro mwhich the phase can be corrected and a real inversion recovery image
obtained. This method has the additional benefit of performing a first order
correction of B1 inhomogeneities, as the same inhomogeneities are
present in both inversion times images and so cancel out. One algorithm to do
this has been published as "MP2RAGE".
mp2rage is a command line program to peform this analysis. Options may
be entered on the same command line; if the minium set of options are not
present then the program will prompt for the relavant missing values. The
phase maps should be scaled to radians, either as floating point pixels or by
using appropriate scaling and offset values in the Analyze header.
mp2rage [-ii] [-zz] [-d] [input_modulus_filename_TI1] [input_phasemap_filename_TI1] [input_modulus_filename_TI2] [input_phasemap_filename_TI2] [output_MP2RAGE_filename]
- -ii
-
The input files may be arranged with each TI in a seperate image file, or the
TIs may be interleaved in the same image file. The default is to assume that the
different TIs are in seperate files, hence requiring filenames for both TIs.
However, if this option is specified, then it is assumed that the input modulus
and phase image files contain both TIs interleaved in the same image file.
- -zz
-
Depending on the MR scanner configuration, the phase map may have been masked
already, with the background intensity values set to zero. If conversion to
radians is to be obtained by using the scaling factor and offset values in the
Analyze header then the background may be converted to -π. By specifying
this option, zero intensities in the input phase map are preserved regardless
of the offset value in the Analyze header. However, the same will occur for
true zero phase values inside the object.
- -d
-
Displays additional diagnostic output.
- input_modulus_filename_TI1
-
The filename of the Analyze file containing the input modulus images acquired
at the first inversion time. Filenames may contain either the .img or .hdr
extension, or neither. If the input_modulus_filename_TI1 is not
specified on the command line then the program will prompt for a filename.
- input_phasemap_filename_TI1
-
The filename of the Analyze file containing the input phase map acquired
at the first inversion time.
- input_modulus_filename_TI2
-
The filename of the Analyze file containing the input modulus images acquired
at the second inversion time. Filenames may contain either the .img or .hdr
extension, or neither.
- input_phasemap_filename_TI2
-
The filename of the Analyze file containing the input phase map acquired
at the second inversion time.
- output_MP2RAGE_filename
-
Analyze file which will contain the calculated MP2RAGE image. If this is not
specificed, then the output filename will default to the first input modulus
filename appended with "mp2rage".
References
- Gowland PA, Leach MO.
"Fast and accurate measurements of T1 using a multi-readout
single inversion-recovery sequence"
Magnetic Resonance in Medicine 26:79-88 (1992)
- Marques JP, Kober T, Krueger G, van der Zwaag W, Van de Moortele PF,
Gruetter R.
"MP2RAGE, a self bias-field corrected sequence for improved segmentation
and T1-mapping at high field"
Neuroimage 49:1271-1281 (2010)